Imran Jamal

This study identifies RBPJ-mediated epigenetic regulation of efferocytosis in macrophages, showing that suppression of H3K9me3 enhances apoptotic cell clearance and suppresses inflammation.

This study shows that macrophage fatty acid synthesis promotes fibroblast expansion and fibrosis after myocardial infarction.

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.