Ricard A. Rodríguez‐Mias

The paper profiles the proteome and phosphoproteome of yeast expressing three mistranslating tRNA variants, showing varied growth defects and impacts on cellular processes.

The paper introduces a rapid and cost-effective method for phosphotyrosine peptide enrichment, enabling sensitive detection of phosphotyrosine sites in biological samples.

The paper identifies TPL's role in nucleating the transcriptional preinitiation complex in yeast and plants through genetic and physical interaction studies.

The paper develops a microscale ex vivo cancer model using tumor cuboids that retain a complex tumor microenvironment, enabling drug and immunotherapy testing.

The paper maps the yeast phosphoproteome under 101 perturbations, identifying 25,000 regulated phosphosites and revealing stress response programs and regulatory networks.

The paper investigates how anticodon mutations in tRNAAla affect yeast growth and mistranslation, finding that anticodon sequence influences mistranslation extent and growth impact.

The paper introduces R2-pY, a robotic method for phosphotyrosine enrichment in proteomics, achieving high efficiency and reproducibility with 96 samples processed in parallel.

This study uses multidimensional proteomics to analyze age-related changes in yeast cells, identifying molecular trajectories of aging and rejuvenation.

The paper introduces a method to coisolate and fragment SILAC peptide pairs for improved identification and quantification in MS/MS-based proteomics.

The paper introduces a proteomic technology called Miro to identify amino acid substitutions that affect protein function by using mistranslation and mass spectrometry.

The paper identifies altered protein networks in the cerebellum of schizophrenia patients and validates findings in murine models of early postnatal stress.

The paper identifies phosphosites that affect protein thermal stability by measuring stability differences between proteins and their phosphorylated forms at a proteomic scale.

DIAmeter is a library-free search engine for analyzing DIA mass spectrometry data using peptide sequences, supporting various isolation windows and post-translational modifications.

The paper identifies altered calcium-binding proteins in the cerebellum of schizophrenia patients, linking them to synaptic dysfunction and suicide behaviors.

The paper introduces R2-P2, an automated phosphoproteomics method, and applies it to study MAPK pathway signaling in yeast, revealing phosphorylation events across multiple pathways.