Ian R.L. Smith

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST

This study uses nMOST to profile proteo-lipidomics in lysosomal storage disease mutants, revealing autophagy defects and mitochondrial dysfunction.

Coisolation of peptide pairs for peptide identification and MS/MS-based quantification

The paper introduces a method to coisolate and fragment SILAC peptide pairs for improved identification and quantification in MS/MS-based proteomics.

Proteome-wide identification of amino acid substitutions deleterious for protein function

The paper introduces a proteomic technology called Miro to identify amino acid substitutions that affect protein function by using mistranslation and mass spectrometry.

Identification of phosphosites that alter protein thermal stability

The paper identifies phosphosites that affect protein thermal stability by measuring stability differences between proteins and their phosphorylated forms at a proteomic scale.