Loss of Gαq reshapes key fibroblast traits and drives matrix remodeling and aggressive progression of oral cancer tumors
Inmaculada Navarro‐Lérida, Raquel Huertas‐Lárez, Gemma Paredes-Garcia, Dafne García-Mateos, Maria Isabel Jimenez-Lopez, Juan Antonio López, Miguel Á. del Pozo, Saúl Álvarez–Teijeiro, Llara Prieto-Fernández, Juana Maria Garcia-Pedrero, Federico Mayor, Catalina Ribas
This study shows that loss of Gαq in fibroblasts promotes aggressive oral cancer progression by altering ECM remodeling, exosome secretion, and tumor cell migration.
bioRxiv · Mar 12, 2025 · PreprintCancer Biology