Functional interrogation uncovers a critical role for a high-plasticity cell state in lung adenocarcinoma
Jason Earl Chan, Chun‐Hao Pan, Jonathan Rub, Gary Guzman, Klavdija Bastl, Emma Brown, Zeda Zhang, Hannah C. Styers, Griffin G. Hartmann, Zhuxuan Li, Xueqian Zhuang, Scott W. Lowe, Doron Betel, Yan Yan, Tuomas Tammela
In vivo lineage tracing and targeted ablation in autochthonous mouse lung adenocarcinoma establish the Slc4a11+ high-plasticity cell state as a bidirectional transition hub driving tumor progression and therapy resistance.
Nature · Jan 21, 2026Peer-reviewedCancer Biology✦ In-depth digest