Author
University Medical Center GroningenORCID 0000-0001-8005-767XUnclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Abel Soto-Gamez, Yi Wu, Eline Hageman…·Robert Paul Coppes
The paper identifies Nutlin3a as a senolytic compound that reduces radiation-induced salivary gland dysfunction by transiently activating p53 in a two-step organoid screening approach.
Rufina Maturi, Davide Cinat, Anne L. Jellema-de Bruin…·Abel Soto-Gamez
This study identifies IFN-β signaling as a key mediator of radiation-induced inflammation and cell death in thyroid organoids, with dual effects on survival and regenerative potential.
Davide Cinat, Ryan van der Wal, Mirjam Baanstra…·Robert Paul Coppes
The paper shows that transposable element derepression triggers IFN-I signaling, boosting stem/progenitor cell activity after irradiation.
Davide Cinat, Rufina Maturi, Jeremy P Gunawan…·Robert Paul Coppes
The paper identifies Notch signaling as essential for maintaining stem/progenitor cell self-renewal and migration post-irradiation in salivary and other gland organoids.