Lara Barazzuol

The paper identifies Nutlin3a as a senolytic compound that reduces radiation-induced salivary gland dysfunction by transiently activating p53 in a two-step organoid screening approach.

The paper shows that transposable element derepression triggers IFN-I signaling, boosting stem/progenitor cell activity after irradiation.

The paper identifies Notch signaling as essential for maintaining stem/progenitor cell self-renewal and migration post-irradiation in salivary and other gland organoids.

This study shows that radiotherapy primes microglia in rats to have a heightened immune response to future inflammation, and this effect is observed in human brain tissue.

This study shows that brain regions in glioblastoma patients exhibit signs of accelerated ageing similar to Alzheimer's disease, suggesting shared mechanisms of mitochondrial and neuronal dysfunction.

The paper shows that targeting ATM, ATR, or DNA topoisomerases causes widespread protein aggregation through chaperone system overload, similar to proteotoxic stress and proteinopathies.