Abel Soto-Gamez

A two-step organoid screen identifies transient p53 activation as a senolytic strategy for radiation-induced salivary gland dysfunction

The paper identifies Nutlin3a as a senolytic compound that reduces radiation-induced salivary gland dysfunction by transiently activating p53 in a two-step organoid screening approach.

Role of Klhl14 in senescence and epithelial-to-mesenchymal transition via TGF- modulation

This study identifies KLHL14's role in maintaining thyroid epithelial identity and regulating tissue homeostasis by modulating TGF-β signaling, with implications for thyroid cancer.

Radiation-induced interferon-I response impairs thyroid organoid function

This study identifies IFN-β signaling as a key mediator of radiation-induced inflammation and cell death in thyroid organoids, with dual effects on survival and regenerative potential.

Notch Signaling Drives Pro-Regenerative and Migratory Traits in Glandular Stem/Progenitor Cells

The paper identifies Notch signaling as essential for maintaining stem/progenitor cell self-renewal and migration post-irradiation in salivary and other gland organoids.

Pharmacological CDK4/6 inhibitors promote senescence-associated lysosomal alterations and enhance sensitivity to lysosomotropic agents in breast cancer

This study shows CDK4/6 inhibitors induce senescence-like changes in breast cancer cells, increasing their sensitivity to lysosomotropic agents, and suggests sequential treatment could improve therapy efficacy.