Gildas Loussouarn

This study shows that common dual-expression systems fail to balance WT and variant hERG expression, leading to inaccurate functional assessments of KCNH2 variants.

MeTAL links KCNH2 variant biophysical properties to ECG phenotypes, revealing nonlinear relationships and improving risk prediction for inherited arrhythmia syndromes.

The paper shows Nav1.2 channels shape the action potential in the axon initial segment by activating BK channels, influencing repolarization.