Michel MDW DE WAARD

This study shows that common dual-expression systems fail to balance WT and variant hERG expression, leading to inaccurate functional assessments of KCNH2 variants.

This paper demonstrates wireless photoactivation of a peptide to modulate cardiac excitability in vivo using an implantable device.

This study identifies rare and low-frequency non-coding variants at the SCN5A locus associated with Brugada syndrome using whole-genome sequencing and functional assays.

MeTAL links KCNH2 variant biophysical properties to ECG phenotypes, revealing nonlinear relationships and improving risk prediction for inherited arrhythmia syndromes.

This study uses automated and manual patch-clamp techniques to analyze Cav3.1 channel variants, identifying gain- and loss-of-function properties linked to neurological disorders.

This study shows that AaH-II selectively activates TTX-S Nav channels, inducing arrhythmias in cardiac tissue, and suggests targeting these channels as an antiarrhythmic strategy.

The paper investigates how the scorpion toxin AaH-II affects action potential generation in the axon initial segment of mouse neurons using high-resolution imaging techniques.

The paper shows Nav1.2 channels shape the action potential in the axon initial segment by activating BK channels, influencing repolarization.