Julián Grandvallet Contreras

The paper investigates tissue-specific chromosomal deletions in BRCA1/2-related cancers using bulk and single-cell data, finding early deletions of 17q and 13q in breast and ovarian cancers.

The paper identifies genomic deletions as the rate-limiting mutational processes in breast and ovarian cancer initiation, requiring 1-3 deletions for tumor development.

This study uses multi-omics approaches to analyze pediatric low-grade glioma and identifies immune-related differences linked to BRAF mutations.