Kent A. Riemondy

This study shows that Arc1 in Drosophila regulates metabolic resilience and developmental timing in response to dietary changes by linking insulin signaling to metabolic and developmental gene expression.

This study investigates how differential phagocytosis induced by RT or anti-CD47 therapy affects macrophage activation states in gliomas, showing that combination therapy reduces tumor growth and induces distinct macrophage states.

This paper introduces a method to simultaneously measure tRNA sequence, modification, and aminoacylation using nanopore sequencing and machine learning.

This study uses multi-omics approaches to analyze pediatric low-grade glioma and identifies immune-related differences linked to BRAF mutations.

The study shows that Z domain mutations in ADAR1p150 slightly reduce A-to-I editing, likely due to mislocalization rather than editing specificity loss, and suggests phenotypes may stem from ZBP1 inhibition.

Subunit vaccines induce CD8+ T cells with memory fate characteristics that maintain proliferative capacity via IL-27 receptor signaling during expansion.

The paper characterizes transcriptome dynamics during the Drosophila MZT using RNA-seq data, revealing zygotic isoforms with distinct regulatory potential and proteomic consequences.

The paper introduces scraps, a pipeline for high-resolution APA detection in scRNA-seq, showing it outperforms existing methods and enables assessment of internal priming events.

The paper identifies RNA-binding proteins and RNA decay factors that regulate aldosterone production kinetics in steroidogenic cells through coordinated transcription and decay mechanisms.

This paper highlights the issue of insufficient metadata in scRNA-seq studies, hindering data reuse and reproducibility, and advocates for improved documentation standards.

clustifyr assigns cell types to scRNA-seq clusters using diverse reference data and provides tools for exploratory analysis.

The paper develops a method to recover and analyze targeted transcriptome subsets from scRNA-seq libraries, improving sequencing depth and gene detection.

The paper quantifies A-to-I RNA editing in hibernating ground squirrels and finds cold-induced editing sites that may provide neuroprotection during torpor.