Synthetic BiologybioRxivPreprint
REWRITE Enables Locus-Scale Engineering of Synthetic HLA Haplotypes in Human Pluripotent Stem Cells
Serena Generoso, Sarah Levovitz, Susanna Jaramillo…·David M. Truong
REWRITE enables scar-minimized rewriting of native human loci exceeding 100 kb in hPSCs, demonstrated through synthetic refactoring of the class-I HLA region.
DOI 10.1101/2025.09.16.676382