Wade D. Van Horn

The paper identifies how diverse TRPV1 antagonists interact with the receptor through different binding modes and highlights conserved inhibited states.

The paper identifies small-molecule modulators of lipid raft stability and protein-raft partitioning, revealing two classes of compounds with distinct mechanisms of action.

This paper characterizes the cyanobacterial metabolite Veraguamide E, showing it binds the sigma-2 receptor with high affinity, modulates calcium signaling in neurons, and lacks cytotoxicity.

This study links TRPM8 protein dynamics to ligand structure and cellular function using NMR, cheminformatics, and electrophysiology.