Author

Jacob K. Hilton

Arizona State UniversityORCID 0000-0003-1931-9516Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Brian R. Cherry· 1 shared Dustin D. LuuiD· 1 shared Eric SefahiD· 1 shared Joanne L. ParkeriD· 1 shared Joseph A. MindelliD· 1 shared Justin C. DemeiD· 1 shared Kaitlyn ParrottiD· 1 shared Marcia LevitusiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Brian R. Cherry

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 1, 2025

Mechanism of phosphoinositide regulation of lysosomal pH via inhibition of CLC-7

Jacob K. Hilton, Yifei Lin, Eric Sefah…·Joseph A. Mindell

The paper investigates how PI(3,5)P2 regulates lysosomal pH by inhibiting ClC-7, showing structural changes in ClC-7 upon PI(3,5)P2 binding and linking this to disease mutations.

1 citation

humanproteomics

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BiophysicsJournal of the American Chemical SocietyPeer-reviewedMay 27, 2025

TRPM8 protein dynamics correlates with ligand structure and cellular function

Mubark D. Mebrat, Dustin D. Luu, Jacob K. Hilton…·Wade D. Van Horn

This study links TRPM8 protein dynamics to ligand structure and cellular function using NMR, cheminformatics, and electrophysiology.

8 citationstop 4%

humanelectrophysiology

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