Beate Koksch

Glycosaminoglycans Promote Amyloid-β Aggregation via Multivalent, pH-Dependent Interactions

This study shows glycosaminoglycans promote amyloid-β aggregation under acidic conditions through pH-dependent electrostatic interactions and multivalency.

HMGB1 B-box domain self-complexes promote protein-polyelectrolyte interactions.

This study shows that HMGB1's B-box domain forms self-associates that enhance interactions with heparin through charge redistribution and conformational changes.

Escherichia coli adapts metabolically to 6- and 7-fluoroindole, enabling proteome-wide fluorotryptophan substitution

This study evolves Escherichia coli to use fluorinated indoles as nutrients, converting them into fluorotryptophan and incorporating them into the proteome.

Laboratory evolution of Escherichia coli enables life based on fluorinated amino acids

This study shows that Escherichia coli can adapt to use fluorinated indoles as essential precursors for protein synthesis through few genetic mutations and significant regulatory and cellular changes.