Jana Sticht

Glycosaminoglycans Promote Amyloid-β Aggregation via Multivalent, pH-Dependent Interactions

This study shows glycosaminoglycans promote amyloid-β aggregation under acidic conditions through pH-dependent electrostatic interactions and multivalency.

Quantitative analysis of MHC class II peptide exchange reveals pivotal role of peptide association rate

The paper develops a kinetic model to explain variation in HLA-DM susceptibility of MHC-II peptides and identifies two mechanisms shaping antigen presentation.

Target Recognition in Tandem WW Domains: Complex Structures for Parallel and Antiparallel Ligand Orientation in h-FBP21 Tandem WW

The paper identifies and characterizes two complex structures of the tandem WW domain of h-FBP21 bound to a peptide from SmB/B, revealing different ligand and domain orientations.