Elgene Lim

The paper identifies stromal cell subsets in breast cancer that influence T-cell infiltration and patient outcomes through spatial and clinical analysis.

This study uses genetic barcoding to analyze clonal composition in solid and liquid biopsies of breast cancer models, revealing differences in clonal diversity and DNA shedding patterns.

This paper shows that ROCK2 inhibition reduces ECM remodelling and cell growth while impairing migration and invasion in breast cancer models.

ProCanFDL uses federated deep learning to subtype cancers using proteomic data while preserving privacy, achieving performance gains over local models.

This study identifies JNK pathway suppression as a driver of resistance to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer, with implications for patient stratification.

This study shows that Decitabine suppresses tumour growth in ER+ breast cancer by inducing DNA hypomethylation and altering 3D chromatin structure.

This study shows DNA hypomethylation disrupts replication timing precision and 3D genome organisation in colorectal cancer DNMT1 and DNMT3B knockout cells.