Author

Grady C. Smith

Garvan Institute of Medical Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:Hi-C· 2 Organism:human· 2 Research Focus:spatial domain detection· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Clare StirzakeriD· 2 shared Elyssa M. CampbelliD· 2 shared Joanna Achinger-KaweckaiD· 2 shared Qian DuiD· 2 shared Susan J. ClarkiD· 2 shared Alicia M. Jones· 1 shared Amanda KhouryiD· 1 shared Anai Gonzalez-CorderoiD· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersGenomics

Clare StirzakerORCID

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Author profile →

3 papers

Recent·Most cited

Androgen stimulation rapidly reorganizes temporal 3D genome and epigenome states to trigger AR-mediated transcription in prostate cancer.

Elyssa M. Campbell, Geraldine Laven‐Law, Alicia M. Jones, Dayna Challis, Timothy J Peters, Grady C. Smith, Yolanda Colino‐Sanguino, David Moulder, Qian Du, Katherine A. Giles, Daniel W. Thomson, Clare Stirzaker, Theresa E. Hickey, Fátima Valdés‐Mora, Amanda Khoury, , Joanna Achinger-Kawecka

This study investigates how androgen stimulation reorganizes 3D genome and epigenome states in prostate cancer cells to activate AR-mediated transcription.

bioRxiv · Dec 17, 2024 · PreprintGenomics

DNA methylation is required to maintain DNA replication timing precision and 3D genome integrity

Qian Du, Grady C. Smith, Phuc‐Loi Luu, James M. Ferguson, Nicola J. Armstrong, Catherine Elizabeth Caldon, Elyssa M. Campbell, Shalima S. Nair, Elena Zotenko, Cathryn M. Gould, Michael J Buckley, Kee-Ming Chia, Neil Portman, Elgene Lim, Dominik C. Kaczorowski, , Susan J. Clark

This study shows DNA hypomethylation disrupts replication timing precision and 3D genome organisation in colorectal cancer DNMT1 and DNMT3B knockout cells.

Cell Reports · Sep 1, 2021Peer-reviewedMolecular Biology

Differentiation of cortical brain organoids and optic nerve-like structures from retinal confluent cultures of pluripotent stem cells

Milan Fernando, Scott David Lee, Jesse Ray Wark, Di Xiao, Hani J. Kim, Grady C. Smith, Ted Wong, Erdahl Teber, Robin R. Ali, Pengyi Yang, Mark Evan Graham, Anai Gonzalez-Cordero

This paper describes a protocol to generate cortical brain organoids and optic nerve-like structures from retinal confluent cultures of pluripotent stem cells, showing transcriptional similarity to fetal cortex and functional network activity.

bioRxiv · May 16, 2021 · PreprintNeuroscience