David Herrmann

Pulsed priming with the FAK inhibitor narmafotinib enhances both gemcitabine/Abraxane and FOLFIRINOX chemotherapy response in pancreatic cancer

This paper shows that pulsed narmafotinib priming improves chemotherapy response in pancreatic cancer by reducing fibrosis and enhancing treatment efficacy.

ROCK2 inhibition has a dual role in reducing ECM remodelling and cell growth, while impairing migration and invasion

This paper shows that ROCK2 inhibition reduces ECM remodelling and cell growth while impairing migration and invasion in breast cancer models.

Defocused reflectance imaging for low numerical aperture, large field of view quantitative live cell imaging studies

This paper demonstrates that controlled defocusing in low numerical aperture microscopes improves automated cell segmentation and tracking for high-throughput live-cell imaging.

Using rotational integration of oblique interferometric scattering (RO-iSCAT) to track axial spatiotemporal responses of membrane protrusions

This paper introduces RO-iSCAT, a technique that enables real-time, label-free tracking of membrane protrusions with high axial resolution and minimal phototoxicity.

Fibroblast Growth Factor-induced lens fiber cell elongation is driven by the stepwise activity of Rho and Rac

This study identifies FGF's role in regulating Rho and Rac activity to drive lens fiber cell elongation and migration during differentiation.