This study compares two single-cell immune profiling technologies, evaluating their performance in transcriptomic and T cell receptor features across human PBMC samples.

bioRxiv · Apr 22, 2026 · PreprintBioinformatics

Androgen stimulation rapidly reorganizes temporal 3D genome and epigenome states to trigger AR-mediated transcription in prostate cancer.

Elyssa M. Campbell, Geraldine Laven‐Law, Alicia M. Jones, Dayna Challis, Timothy J Peters, Grady C. Smith, Yolanda Colino‐Sanguino, David Moulder, Qian Du, Katherine A. Giles, Daniel W. Thomson, Clare Stirzaker, Theresa E. Hickey, Fátima Valdés‐Mora, Amanda Khoury, , Joanna Achinger-Kawecka

This study investigates how androgen stimulation reorganizes 3D genome and epigenome states in prostate cancer cells to activate AR-mediated transcription.

bioRxiv · Dec 17, 2024 · PreprintGenomics

Epigenetic therapy targets the 3D epigenome in endocrine-resistant breast cancer

Joanna Achinger-Kawecka, Clare Stirzaker, Neil Portman, Elyssa M. Campbell, Kee-Ming Chia, Qian Du, Geraldine Laven‐Law, Shalima S. Nair, Aliza Yong, Ashleigh Wilkinson, Samuel Clifton, Heloisa Helena Milioli, Sarah Alexandrou, Catherine Elizabeth Caldon, Jenny Z. Song, , Susan J. Clark

This study shows that Decitabine suppresses tumour growth in ER+ breast cancer by inducing DNA hypomethylation and altering 3D chromatin structure.

Nature Structural & Molecular Biology · Jan 5, 2024Peer-reviewedMolecular Biology

DNA methylation is required to maintain DNA replication timing precision and 3D genome integrity

Qian Du, Grady C. Smith, Phuc‐Loi Luu, James M. Ferguson, Nicola J. Armstrong, Catherine Elizabeth Caldon, Elyssa M. Campbell, Shalima S. Nair, Elena Zotenko, Cathryn M. Gould, Michael J Buckley, Kee-Ming Chia, Neil Portman, Elgene Lim, Dominik C. Kaczorowski, , Susan J. Clark

This study shows DNA hypomethylation disrupts replication timing precision and 3D genome organisation in colorectal cancer DNMT1 and DNMT3B knockout cells.

Cell Reports · Sep 1, 2021Peer-reviewedMolecular Biology

BRG1 promotes transcriptional patterns that are permissive to proliferation in cancer cells

Katherine A. Giles, Cathryn M. Gould, Joanna Achinger-Kawecka, Scott G. Page, Georgia Rose Kafer, Phuc‐Loi Luu, Anthony J. Cesare, Susan J. Clark, Phillippa C. Taberlay

This study shows BRG1 promotes proliferation in prostate cancer by regulating gene expression related to cell cycle and DNA replication, independent of AR and FOXA1.

bioRxiv · Jul 3, 2020 · PreprintMolecular Biology