Andrew Lezia

This study improves genetic circuit function in E. coli by evolving strains in complex environments using adaptive laboratory evolution.

This study shows that using plasmids with identical origins of replication in synthetic bacterial systems can enable population adaptation through copy number coupling and memory.

The paper develops a workflow combining directed mutagenesis and microfluidics to create and tune dynamic gene circuits, resulting in a robust genetic oscillator with controlled period-amplitude characteristics.