Rory R. Sheng

This paper develops biodegradable intra-arterial drug delivery devices for targeted organ treatment, showing improved drug levels in the kidney and brain compared to oral administration.

The paper identifies key regulatory elements in bat limb development by comparing bat and mouse genomic datasets and swapping enhancer sequences to observe phenotypic changes.

The paper identifies a female-biased tail abnormality caused by deletion of Pax1 regulatory elements in mice, linking it to estrogen signaling and AIS susceptibility.

This study identifies a genetic variant in COL11A1 associated with adolescent idiopathic scoliosis and proposes a molecular model involving Pax1, Col11a1, and Mmp3 in spinal chondrocytes.

The paper integrates single-cell RNA and ATAC-seq data from mouse and human hypothalamus to identify sex-specific genes and obesity-associated regulatory elements.

This study identifies ADGRG6 as a gene involved in adipogenesis and sex-specific fat distribution, showing its potential as a therapeutic target for metabolic disease.