Paul D. Coleman

This study identifies cell-type-specific epigenetic changes in TNXB in Alzheimer's disease using bulk and single-cell analyses of the dorsal raphe nucleus.

This study performs a meta-analysis of DNA methylation data from Alzheimer's disease patients to identify differentially methylated loci across brain regions and cortex.

This paper introduces a highly sensitive in situ proteomics method using cleavable fluorescent tyramide and antibodies, enabling detailed analysis of protein expression in human tissues.

This paper introduces a method for highly sensitive and multiplexed in situ protein profiling using cleavable fluorescent streptavidin and biotin conjugated antibodies, achieving 10-fold improved sensitivity over existing methods.