Yixuan Wu

This paper introduces EnzHier, a machine learning algorithm that improves enzyme function prediction by integrating sequence, structural information, and functional hierarchy, achieving better accuracy than existing tools.

This study identifies Nudt12 as a new deNADding enzyme distinct from DXO, showing it targets NAD-capped RNAs and links these RNAs to cellular metabolism.

The paper identifies INTS4 as a conserved interaction partner of INTS9/11, forming a heterotrimeric complex critical for UsnRNA biogenesis.