Thomas C. Marlovits

The paper structures the Wza-Wzc complex from E. coli K12 using cryo-EM, revealing its role in CPS transport and identifying a CPS-binding domain.

This paper develops a method to compute residue-scale elastic pseudoenergy in proteins and applies it to RuvB to elucidate the energetic basis of its hand-over-hand mechanism.

The paper identifies a new evolutionarily conserved short linear F-actin binding motif and develops a computational pipeline to identify its containing proteins.

The paper investigates the structural dynamics of SctV, a component of the Type III translocase export gate in E. coli, revealing its conformational changes and interactions with chaperones and ATPase.

The paper reports the structure of an active Salmonella T3SS needle complex engaged with SptP, revealing the mechanism of unfolded protein translocation through the secretion conduit.

This study reveals the structural control of type-3 secretion system assembly in Salmonella, showing how structural features guide the formation of a 24:16/15 basal body and regulate protein secretion.