Sean Miletic

This paper designs potent small protein inhibitors of C. difficile toxin B using deep learning and Rosetta, showing high affinity and stability for potential clinical use.

The paper reports the structure of an active Salmonella T3SS needle complex engaged with SptP, revealing the mechanism of unfolded protein translocation through the secretion conduit.

This study reveals the structural control of type-3 secretion system assembly in Salmonella, showing how structural features guide the formation of a 24:16/15 basal body and regulate protein secretion.