Christian Sieben

This study shows that Arp2/3 complex-dependent actin remodeling is necessary for efficient RSV uncoating in A549 cells, as Arp2 knockout cells exhibit reduced infection and viral mRNA expression.

The paper structures the Wza-Wzc complex from E. coli K12 using cryo-EM, revealing its role in CPS transport and identifying a CPS-binding domain.

This paper introduces a deep learning model to identify virus-infected cells from light microscopy images without using labels or stains, achieving up to 96% classification accuracy.

This study shows that glial cells, particularly astrocytes, promote HPAIV H7N7 infection in vitro by acting as primary virus producers, with microglia initiating pro-inflammatory responses.

This study uses single-molecule microscopy to investigate influenza A virus-induced nanoscale cellular changes at the virus-cell interface, revealing receptor dynamics and actin cortex responses.

This study shows that bat influenza A virus H18N11 attaches to MHCII clusters on host cells, causing local clustering of MHCII molecules similar to immunological synapse formation.

This study shows membrane tension drives NINJ1 filament opening, causing cell lysis, and explains why NINJ2 fails to form lesions.

Enso decodes bacterial cell cycle and cell type from static SMLM images using unsupervised deep learning without prior knowledge.

The paper investigates how NF-kB (p65) DNA binding time relates to transcriptional activation by analyzing mutants affecting DNA binding and protein-protein interaction domains.

This study uses glycan arrays and single-virus force spectroscopy to show that influenza A virus receptor binding preference does not always match cell specificity.