Jun Yang

This study shows that inhibiting soluble epoxide hydrolase with TPPU improves cognitive function in diabetic-related dementia by enhancing cerebral blood flow and reducing neuroinflammation and gliosis.

This study shows that inhibiting soluble epoxide hydrolase reduces inflammation and myocardial injury in arrhythmogenic cardiomyopathy by increasing pro-resolving lipid mediators.

This study shows that inhibiting soluble epoxide hydrolase (sEH) with TPPU improves cerebral blood flow autoregulation and cognition in Alzheimer's and diabetes-related dementia rat models.

This study shows that P2-HNF4 regulates ketogenesis in the liver and is involved in circadian metabolism, with implications for gender-specific ketone body levels.

The paper identifies EPHX1 mutations causing lipoatrophic diabetes through impaired epoxide hydrolysis and increased cellular senescence, with metreleptin therapy showing benefit.