The Notch signaling pathway is a master regulator of CD8+ T cell exhaustion and differentiation during chronic infection
Dave Maurice De Sousa, Salix Boulet, Frédéric Duval, Eric Perkey, Jean‐François Daudelin, Laure Le Corre, Marie‐Ève Lebel, Alain Lamarre, Freddy Radtke, Burkhard Ludewig, Christian W. Siebel, Ivan Maillard, Nathalie Labrecque
This study shows that Notch signaling regulates CD8+ T cell exhaustion and differentiation during chronic infection by promoting the transition from progenitor to effector-like cells and preventing terminal exhaustion.
bioRxiv · Sep 5, 2026 · PreprintImmunology