Viktoria Kohlhas

This study shows that systemic MIF is critical for CLL development, regardless of its cellular source, as Mif-deficient hosts resist disease despite adaptive transfer of CLL cells.

This study shows that reducing CSF1R expression in myeloid cells has limited impact on CLL progression, suggesting that targeting CSF1R alone may not be effective for therapy.

The paper compares macrophage feeder systems to assess their effects on chronic lymphocytic leukemia cells, including phagocytosis, treatment resistance, and transcriptional changes.