Phuong‐Hien Nguyen

Tumour-derived factors prime microglia for immune checkpoint-mediated T-cell regulation

This study identifies an early microglial activation program driven by soluble factors from tumors, leading to immune checkpoint regulation and immunosuppression in brain tumors.

Systemic MIF facilitates chronic lymphocytic leukemia development independent of its cellular source

This study shows that systemic MIF is critical for CLL development, regardless of its cellular source, as Mif-deficient hosts resist disease despite adaptive transfer of CLL cells.

Single recipient cell tracking of tellurium-labeled extracellular vesicle proteomes (TeLEV) identifies EV-driven immunomodulation

The paper introduces TeLEV, a method to track EV proteomes in immune cells, revealing EV-driven immunomodulation through STAT5-dependent mechanisms.

Reduced CSF1R expression in myeloid cells has limited impact on chronic lymphocytic leukemia progression

This study shows that reducing CSF1R expression in myeloid cells has limited impact on CLL progression, suggesting that targeting CSF1R alone may not be effective for therapy.

Comparative analysis of macrophage feeder systems reveals distinct behaviors and key transcriptional shifts in chronic lymphocytic leukemia cells via coculture

The paper compares macrophage feeder systems to assess their effects on chronic lymphocytic leukemia cells, including phagocytosis, treatment resistance, and transcriptional changes.