Wenhui Hu

This study shows that TLR3 activation in human iPSC-derived microglia-containing cerebral organoids induces antiviral factors against HIV-1.

AAVone is a single-plasmid system for AAV production that increases yield, reduces DNA impurities, and simplifies the manufacturing process.

This study presents cryo-EM structures of human GPR155, revealing its transporter and GPCR domains' conformations and cholesterol-dependent dimerization.

The paper identifies a microglia-specific promoter of the human HexB gene that can be used for AAV gene therapy targeting microglia in the CNS.