Therapeutic Eradication of Cancer-associated Fibroblasts Inhibits in vivo progression of Pancreatic Cancer
Matilda Roos-Mattila, Harri K. Mustonen, Markus J. V. Vähä-Koskela, Sonja Boyd, Sanna Vainionpää, Rosa F. Hwang, Pauli Antero Puolakkainen, Vadim Le Joncour, Pirjo Maarit Laakkonen, Hanna E. Seppänen
This study shows that clemastine eradicates cancer-associated fibroblasts, halts pancreatic cancer progression, and synergizes with gemcitabine to inhibit metastasis.
bioRxiv · Nov 4, 2025 · PreprintCancer Biology