Enhanced lung delivery of an immunostimulatory duplex RNA augments the antitumor activity by reshaping systemic cytokine pharmacodynamics
Eliz Amar‐Lewis, Alexander M. Cryer, Jie Ji, Chaitra Belgur, Anastasia Ershova, Nelly Andrews Interiano, William Sawyer, Zohar Pode, Namrata Ramani, Juan Carlos Oliva Estrada, Nathalie Nicole Casteele Hernandez, John F. K. Sauld, Yuncheng Man, Sylvie G. Bernier, Amanda R. Graveline, , Natalie Artzi
This study shows that lung-targeted delivery of immunostimulatory dsRNA via LNPs enhances systemic cytokine responses and antitumor activity in melanoma models.
bioRxiv · May 4, 2026 · PreprintBioengineering