Author

Melissa N. Locke

University of California, BerkeleyORCID 0000-0001-8162-1471Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Adelle P. McFarlandiD· 1 shared Alexander MarsoniD· 1 shared Alexis GuentheriD· 1 shared Beeke WienertiD· 1 shared Bruce R. ConkliniD· 1 shared Chelsea E. StammiD· 1 shared Chris D. RichardsoniD· 1 shared David N. NguyeniD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMicrobiology

Adelle P. McFarlandORCID

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2 papers

Recent·Most cited

MicrobiologymBioPeer-reviewedJun 28, 2024

RECON gene disruption enhances host resistance to enable genome-wide evaluation of intracellular pathogen fitness during infection.

Chelsea E. Stamm, Adelle P. McFarland, Melissa N. Locke…·Joshua John Woodward

This paper uses a RECON-/- mouse model to perform Tn-seq screening of Listeria monocytogenes in vivo, identifying novel genes critical for bacterial survival and revealing the role of the D-allose operon in pathogenesis.

8 citations

mouseexperimental assay

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Molecular BiologyNature CommunicationsPeer-reviewedApr 30, 2020

Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair

Beeke Wienert, David N. Nguyen, Alexis Guenther…·Jacob E. Corn

The paper identifies CDC7 inhibition as a method to enhance HDR efficiency in CRISPR-Cas9 gene editing by inducing an early S-phase cell cycle arrest.

109 citationstop 2%

humanCRISPR screen

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