H. Leighton Grimes

This study uses single-cell multiomic analysis to reveal genotype-immunophenotype relationships and clonal evolution in NPM1-mutant AML across disease stages.

The paper identifies a splicing mechanism in AML independent of mutations, showing it drives poor prognosis and can be targeted with PRMT5 inhibition.

scTriangulate identifies high-confidence cell populations and modality-specific subtypes by combining clustering results from uni- and multimodal single-cell data using a game-theory framework.

DoubletDecon identifies and removes doublets in scRNA-Seq data using deconvolution and cell-state gene expression analysis, improving cell state delineation.

cellHarmony matches and compares single-cell transcriptomes to identify disease-specific gene regulatory programs and cell-state changes.