Guangyuan Li

This study shows that cold stress suppresses myogenesis in skeletal muscle stem cells of hibernating Syrian hamsters, delaying muscle regeneration without affecting cell viability.

The paper identifies two categories of transcription factor isoforms with distinct molecular functions and shows they contribute to gene regulatory complexity.

ImmunoVerse integrates RNA-Seq and immunopeptidomes to catalog 28,446 tumor-specific HLA-presented antigens across 21 cancers, including a splicing-derived PMEL peptide with T cell expansion support.

This paper introduces BayesTS, a Bayesian probabilistic score for tumor specificity to prioritize drug targets, demonstrating its effectiveness across multiple tissues and data types.

The paper constructs a single-cell reference atlas for human and mouse lung tissues to improve cell type annotation and data integration.

scTriangulate identifies high-confidence cell populations and modality-specific subtypes by combining clustering results from uni- and multimodal single-cell data using a game-theory framework.

CellDrift identifies temporally varied perturbation patterns in single-cell data by analyzing covarying gene expression across time, outperforming existing methods in imputation and pattern detection.

TEsorter classifies transposable elements at the lineage level using conserved protein domains, offering speed, sensitivity, and precision for LTR retrotransposons.

DeepImmuno predicts and generates immunogenic peptides using deep learning models, outperforming existing methods and providing insights into T cell antigen recognition.