Daniel N. Kazdal

This study shows that Magel2 deficiency in a mouse model of Prader-Willi syndrome causes microglial structural changes and increased synaptic engulfment, altering neuron-microglia interactions and hypothalamic circuit function.

This study shows that loss of the Y chromosome in lung adenocarcinoma causes epigenetic and transcriptomic changes that increase lineage plasticity and poor clinical outcomes.

The paper shows that activating the NRF2 pathway can safely increase the dose of TXNRD1 inhibitors in SCLC treatment without harming healthy tissues.

The paper introduces autoSP3, an automated proteomics workflow for low-input clinical samples, demonstrating reproducible quantification of 500-1000 proteins from 100-1000 cells and application to FFPE lung cancer samples.