Mathias Kalxdorf

CRISPR screens establish regulatory maps of immunosuppressive surface molecules in cancer

The paper uses CRISPR screens to identify regulators of immunosuppressive surface molecules in cancer cells, finding DNAJC13 as a key regulator that enhances T-cell sensitivity and tumor survival.

Pharmacoproteomic profiling identifies secreted markers for aberrant drug action

The paper uses proteomics to identify secreted markers linked to drug-induced liver injury and adverse drug reactions by analyzing the secretome of hepatocytes exposed to various drugs.

IceR improves proteome coverage and data completeness in global and single-cell proteomics

IceR improves proteome coverage and data completeness in global and single-cell proteomics by combining DDA's identification rates with DIA's low missing value rates.

Automated sample preparation with SP3 for low-input clinical proteomics

The paper introduces autoSP3, an automated proteomics workflow for low-input clinical samples, demonstrating reproducible quantification of 500-1000 proteins from 100-1000 cells and application to FFPE lung cancer samples.

Proteome thermal stability reflects organ physiology and identifies drug-target engagement in vivo

This study introduces tissue-TPP and blood-CETSA to measure proteome thermal stability, revealing organ physiology and drug-target engagement in vivo.