Marian H. Hettiaratchi

This paper designs BMP-2 binders using AI pipelines to control bone regeneration, finding a binder with 2.07 nM affinity for BMP-2.

This study develops affibody-conjugated hydrogels to phase the delivery of VEGF, FGF-2, and PDGF, enhancing in vitro angiogenesis by 2.8-fold in vascular network length and 4.1-fold in branching.

This paper develops IL-4-specific affibodies to control cytokine delivery and bioactivity, showing reduced IL-4 release and partial signaling inhibition in macrophages.

This study develops a hyaluronic acid-alginate hydrogel modified with ECM-derived peptides to support the generation and maturation of V2a interneurons for CNS tissue repair.

This paper develops a hydrogel system that combines mechanical reinforcement with affinity-controlled BMP-2 release to improve bone regeneration in rat models.

This paper develops HA-coated MEW scaffolds that enhance myoblast attachment, alignment, and differentiation compared to non-coated scaffolds.

This paper engineers affibodies with tunable affinities for VEGF and PDGF using computational design and yeast display to improve controlled protein release from hydrogels.

This paper develops open-source software for automated analysis of 3D tumor models using non-confocal microscopy, achieving accurate drug sensitivity measurements and significantly reducing processing time.

This study compares synthetic and recombinant BMP-2-specific affibodies, finding they have similar structure and function but synthetic ones have lower endotoxin levels and higher yield.