Justin E. Svendsen

From Code to Cure: Computationally Designed BMP-2 Binders Using AI-Integrated Pipelines for Controlled Bone Regeneration

This paper designs BMP-2 binders using AI pipelines to control bone regeneration, finding a binder with 2.07 nM affinity for BMP-2.

Phased affinity-controlled delivery of vascular endothelial growth factor, fibroblast growth factor-2, and platelet derived growth factor enhances in vitro angiogenesis

This study develops affibody-conjugated hydrogels to phase the delivery of VEGF, FGF-2, and PDGF, enhancing in vitro angiogenesis by 2.8-fold in vascular network length and 4.1-fold in branching.

Discovery and Characterization of Interleukin-4-Specific Affibodies for Affinity-Controlled Protein Release and Macrophage Polarization

This paper develops IL-4-specific affibodies to control cytokine delivery and bioactivity, showing reduced IL-4 release and partial signaling inhibition in macrophages.

Applying computational protein design to engineer affibodies for affinity-controlled delivery of vascular endothelial growth factor and platelet-derived growth factor

This paper engineers affibodies with tunable affinities for VEGF and PDGF using computational design and yeast display to improve controlled protein release from hydrogels.

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors

This paper presents computational methods for designing GPCR-binding miniproteins and validates them through high-throughput screening, producing agonists and antagonists for multiple GPCRs.