Su‐Ren Chen

This study shows that CFAP77 is essential for connecting axonemal A and B tubules in mammalian sperm, as its loss disrupts the CFAP77-CCDC105-TEX43 complex and impairs sperm motility.

The paper solves the in-cell structure of mouse sperm central apparatus at sub-nanometer resolution and identifies proteins critical for its asymmetric assembly.

This study identifies IQCH as a gene critical for male fertility, showing that its deficiency causes infertility in humans and mice through defects in sperm structure and function.

This study identifies CFAP52 mutations as a cause of male infertility with sperm head-tail connection and flagella defects in humans and mice, showing CFAP52's role in sperm development and potential as a diagnostic target.