Cláudia M. Vicente

This study shows that isovalerate, a gut microbiota metabolite, enhances epithelial barrier function in porcine ileum organoid-derived cell monolayers by upregulating immunity and absorptive cell markers while reducing stem cell and mucus genes.

This study identifies a FAD-dependent monooxygenase essential for diazo group installation in kinamycin biosynthesis in Streptomyces ambofaciens and expands the biosynthetic gene cluster.

The paper describes the engineering of Bacillus methanolicus to enhance L-glutamate and GABA production through systems-level analysis and metabolic engineering.

SYNTERUPTOR identifies genomic islands containing specialised metabolite gene clusters in microbial genomes, detecting clusters missed by existing tools.

The paper performs 13C metabolic flux analysis on B. methanolicus to compare methylotrophic and non-methylotrophic metabolic states and better understand its metabolism.

The paper designs a synthetic methanol utilization pathway in E. coli by combining methylotrophic enzymes from different sources and optimizing it for increased methanol assimilation.