Author

Laurence Hôtel

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:protein folding & dynamics· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Bertrand AigleiD· 3 shared Cláudia M. VicenteiD· 2 shared Alexis BoutilliatiD· 1 shared Alicia Chateau· 1 shared Amélie Garénaux· 1 shared Annabelle ThibessardiD· 1 shared Cédric ParisiD· 1 shared Christophe JacobiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

Bertrand AigleORCID

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Author profile →

3 papers

Recent·Most cited

Role of a FAD-dependent monooxygenase in diazo group functionalisation of kinamycin in Streptomyces ambofaciens

Cláudia M. Vicente, Alexis Boutilliat, Laurence Hôtel, Cédric Paris, Bertrand Aigle

This study identifies a FAD-dependent monooxygenase essential for diazo group installation in kinamycin biosynthesis in Streptomyces ambofaciens and expands the biosynthetic gene cluster.

Microbiology · Jun 20, 2025Peer-reviewedMicrobiology

Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues

Ли Су, Souaibou Yaouba, Laurence Hôtel, Christophe Jacob, Peter Grün, Yan‐Ni Shi, Alicia Chateau, Sophie Pinel, Helge B. Bode, Bertrand Aigle, Kira J. Weissman

This paper uses mutasynthesis to generate stambomycin derivatives by engineering a bacterial strain and leveraging a promiscuous acyl transferase domain, resulting in new analogues with similar or reduced bioactivity.

Chemical Science · Jan 1, 2025Peer-reviewedSynthetic Biology

SYNTERUPTOR: mining genomic islands for non-classical specialised metabolite gene clusters

Drago Haas, Matthieu Barba, Cláudia M. Vicente, Šarká Nezbedová, Amélie Garénaux, Stéphanie Bury‐Moné, Jean-Noël Lorenzi, Laurence Hôtel, Luisa Laureti, Annabelle Thibessard, Géraldine Le Goff, Jamal Ouazzani, Pierre Leblond, Bertrand Aigle, Jean‐Luc Pernodet, , Sylvie Lautru

SYNTERUPTOR identifies genomic islands containing specialised metabolite gene clusters in microbial genomes, detecting clusters missed by existing tools.

NAR Genomics and Bioinformatics · Apr 4, 2024Peer-reviewedBioinformatics