ImmunologybioRxivPreprint
A new humanized TCR transgenic mouse model to study citrullinated tenascin C reactive T cells relevant to rheumatoid arthritis
Marlene Schülein, M. Gomes Afonso, Merel Sijbranda…·Bruno Raposo
DOI 10.64898/2026.02.12.705563
Author
Karolinska University HospitalORCID 0000-0001-8220-5015Unclaimed ORCID profile · follow to get notified of new preprints
2 papers
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Marlene Schülein, M. Gomes Afonso, Merel Sijbranda…·Bruno Raposo
Gustaf Hederoth, Jielu Liu, Ana Godec…·Greta Hultqvist
This study engineered sialylation on a scFv-based therapeutic to reduce anti-drug antibodies but found no significant impact on immunogenicity or pharmacokinetics in mice.