BioengineeringbioRxivPreprint
Engineered Fab glycosylation of a blood-brain barrier transporter single-chain variable fragment preserved functionality but did not impact anti-drug antibody formation
Gustaf Hederoth, Jielu Liu, Ana Godec…·Greta Hultqvist
This study engineered sialylation on a scFv-based therapeutic to reduce anti-drug antibodies but found no significant impact on immunogenicity or pharmacokinetics in mice.
DOI 10.1101/2025.11.28.691100