Greta Hultqvist

Paralemmin-2 is a membrane-anchored cytoskeletal constituent of Axon Initial Segments and nodes of Ranvier

This study identifies Paralemmin-2 as a component of axon initial segments and nodes of Ranvier, showing its role in modulating the submembrane cytoskeleton and neuronal excitability.

Engineered Fab glycosylation of a blood-brain barrier transporter single-chain variable fragment preserved functionality but did not impact anti-drug antibody formation

This study engineered sialylation on a scFv-based therapeutic to reduce anti-drug antibodies but found no significant impact on immunogenicity or pharmacokinetics in mice.

Paralemmin-3 sustains the integrity of the lateral plasma membrane and subsurface cisternae of auditory hair cells

This study identifies Paralemmin-3 as a critical protein for maintaining the structural integrity of the lateral wall in auditory hair cells, with its loss causing hearing impairment and structural collapse.

Early astrocytic dysfunction is associated to mistuned synapses as well as anxiety and depressive-like behavior in the AppNL-F mouse model of Alzheimers disease

The paper investigates early synaptic dysfunction and emotional behavior in AppNL-F mice, finding reactive astrocytes contribute to synaptic mistuning before Aβ plaques and are linked to depressive-like behavior.