Cancer BiologybioRxivPreprint
PRMT5 is Frequently Upregulated and a Potential Therapeutic Target in MTAP-deficient Malignant Peripheral Nerve Sheath Tumors
Dingxun Wang, Melissa L. Fishel, Azadeh Samiei…·Guangjun Zhang
This paper identifies PRMT5 as a therapeutic target in MTAP-deficient MPNSTs, showing that its inhibition suppresses cell growth and enhances DNA damage when combined with chemotherapy.
DOI 10.64898/2026.03.09.710638