Guangjun Zhang

Spatiotemporal expression of the zebrafish pax9 gene that is essential for median fin patterning

This study investigates the spatiotemporal expression of the zebrafish pax9 gene and its role in median fin patterning using CRISPR-Cas9 knockin and knockout models.

Pax9 governs anterior identity and deployment of sclerotome to the median fins

This study shows that Pax9 is essential for anterior identity and proper deployment of sclerotome cells in the caudal fin of zebrafish, leading to fusion with the anal fin and altered skeletal development.

Evolutionary analysis of vertebrate KCNH voltage-gated potassium channels and their expression in zebrafish embryos

The paper analyzes the evolutionary history and embryonic expression of KCNH voltage-gated potassium channels in zebrafish, revealing their origins in invertebrates and expanded gene numbers in vertebrates.

Piezo3 is a novel mechanosensitive Piezo ion channel in vertebrates

The paper identifies Piezo3 as a new PIEZO paralog in vertebrates, shows its mechanosensitive function in HEK293T cells, and demonstrates its role in zebrafish mechanosensation and light response.

PRMT5 is Frequently Upregulated and a Potential Therapeutic Target in MTAP-deficient Malignant Peripheral Nerve Sheath Tumors

This paper identifies PRMT5 as a therapeutic target in MTAP-deficient MPNSTs, showing that its inhibition suppresses cell growth and enhances DNA damage when combined with chemotherapy.

Inwardly rectifying potassium channels regulate membrane potential polarization and direction sensing during neutrophil chemotaxis

This study identifies Kir7.1's role in maintaining membrane potential and directional sensing during neutrophil chemotaxis, showing its necessity for polarized depolarization and chemotactic movement.

Tissue-specific modification of cellular bioelectrical activities using the chemogenetic tool, DREADD, in zebrafish

This study demonstrates the use of DREADD to manipulate tissue-specific bioelectrical activities in zebrafish, showing voltage changes and morphological effects in melanophores, epidermis, and neurons.

A CRISPR/Cas9 vector system for neutrophil-specific gene disruption in zebrafish

This paper develops a CRISPR/Cas9 system for neutrophil-specific gene disruption in zebrafish and demonstrates its utility in studying gene function.